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Figure 4 Supramolecular approach to a


biological problem. Cyclic peptides with


alternating D- and L-amino acids create a flat,


ring-shaped synthon. When several cyclic


peptides are stacked together they can self-


assemble into a stable nanotube. The walls of the


tube are -pleated sheets. In mice, these


nanotubes have selective antibacterial activity by


increasing the permeability of bacterial


membranes¹⁷. (The structure shown here


features different side groups from those used by


Fernandez-Lopez et al. in ref. 17.)


© 2001 Macmillan Magazines Ltd


NATURE | VOL 412 | 26 JULY 2001 | www.nature.com


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