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groups (CO2H) form a synthon based on


extended O-HO and C-HO bonds. In


4-bromocubanecarboxylic acid, for example,


the C-HO hydrogen bond provides the


overall synthon with additional support11. It is


thought that without this interaction, the


exotic topology could not be realized.


bonds and break the weakest. But in


supramolecular chemistry, there are so many


possible interactions that you have to


consider both the enthalpy and entropy (dis-


order) inherent in every interaction. It is


surprising, then, that although putative


crystal structures can be similar in terms of


energy, many organic molecules yield only


one crystal structure under given conditions.


Molecules seem to know how to crystallize


into the correct structure, even if chemists


cannot predict it.


Crystallization is a complex but highly


efficient process in which a number of mol-


ecular groups compete with each other to be


sites for intermolecular interactions that


might lead to a stable crystal structure.


Before the earliest stage of crystallization


known as nucleation — all molecular groups


present in the solution try out different


possible routes to alternative intermolecular


interactions. But only a few of these inter-


actions will be thermodynamically, kineti-


cally or statistically sustained. The stable


interactions lead to robust synthons and


alternative possibilities are quickly and effi-


ciently excluded. In this respect, there are


similarities between the crystallization of


a small organic molecule and the folding


of a protein. Both proceed through inter-


mediate, structure-determining clusters,


resulting in a considerable increase in


crystallization or folding efficiency.


A fascinating example of such a mechan-


ism is provided by molybdenum chemistry.


Molybdenum can form giant molecular


clusters or rings with nanometre-sized


cavities. Addition of two Mo36 'hub-caps' to


the wheel-like Mo176 cluster results in a Mo248


cluster13. The hub-caps are not stable in


solution, showing that crystallization can


proceed in steps, with complex structures


forming from more simple ones that are not


necessarily stable on their own.



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